对不复杂链球菌和肠球菌细菌病的处方实践的表征:NARRATE研究
Tracy Liu1, Michelle Hinch2, Victor Leung3
1, PharmD, ACPR, is with Lower Mainland Pharmacy Services, Fraser Health Authority and the The University of British Columbia, Vancouver, British Columbia.
The Canadian journal of hospital pharmacy
|January 11, 2024
概括
这项关于血流感染 (BSI) 的研究发现,对于链球菌和肠球菌BSI,过渡到口服抗生素是安全有效的. 较短的抗生素持续时间得到了这些发现对不复杂的BSI的支持.
科学领域:
- 传染性疾病 传染性疾病
- 临床药房 临床药房
- 抗微生物药物管理管理委员会
背景情况:
- 血流感染 (BSI) 是北美主要的死亡原因.
- 对于BSI的抗生素处方存在显著差异.
- 不复杂的链球菌和肠球菌BSI为优化治疗方案提供了机会.
研究的目的:
- 评估当前对不复杂的链球菌和肠球菌BSI的抗生素处方实践.
- 分析抗生素治疗的持续时间和口服过渡的时间.
- 评估不同治疗持续时间和途径的安全性和有效性.
主要方法:
- 成年患者无并发性链球菌或肠球菌BSI的回顾性队列研究.
- 纳入标准:诊断为BSI,年龄≥18岁.
- 排除标准:多微生物细菌病,根深蒂固的感染,短期住院.
主要成果:
- 对于BSI,总治疗持续时间的中位数约为2周.
- 肺炎链球菌 (Streptococcus pneumoniae) 的BSI显示了更短的静脉注射疗法持续时间和更快的口服过渡.
- 在过渡到口服抗生素后,没有观察到复发性BSI.
结论:
- 较短的抗生素持续时间和口服治疗过渡是不复杂的BSI的可行方法.
- 需要进一步的研究来确定口服抗生素过渡的最佳时间.
- 调查结果支持在管理BSI方面进行的抗菌药物管理工作.
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