心脏手术引起心周炎症反应,与心肺旁路后系统性炎症相比,这些反应是不同的
Ali Fatehi Hassanabad1,2, Friederike I Schoettler1,2,3, William D T Kent1,2
1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
JTCVS open
|January 11, 2024
概括
心脏手术导致心周空间局部炎症,与全身反应不同. 这种局部免疫媒介特征可能会影响术后并发症,如心房动.
科学领域:
- 心血管外科心血管外科
- 免疫学 免疫学 免疫学
- 翻译医学是一种翻译医学.
背景情况:
- 通过心肺绕道心脏手术诱导全身炎症.
- 手术后的局部心脏内炎症与心房动和粘附等临床问题有关.
- 心周空间中的免疫调解器与这些并发症有关.
研究的目的:
- 为了研究心脏手术后心周空间的局部炎症反应.
- 为了比较心周液中的免疫细胞群和炎症媒介与周围血液中的免疫细胞群.
- 了解心脏外科手术后心脏空间中独特的炎症概况.
主要方法:
- 潜在的试点临床研究涉及12名接受冠状动脉旁路移植手术的患者.
- 在基线和手术后48小时采集心周液和血液样本.
- 流细胞计用于免疫细胞分析和多重分析用于炎症媒介.
主要成果:
- 中性粒细胞在手术后的心周液和血液中占主导地位.
- 巨细胞 (CD163lo和CD163hi) 在心周液和血液之间呈现差异分布.
- 与手术后的血液相比,在心周空间中发现IL-6,IL-8,MMP-3,MMP-8,MMP-9和TGF-β的度显著更高.
结论:
- 心脏手术会在心周空间内引发独特的炎症反应.
- 这种局部性炎症与全身性炎症反应有显著差异.
- 需要进一步的研究来确定这种独特的局部炎症是否会影响术后并发症,并且可以在治疗上定位.
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