扩展性多切除/脱皮和高热性手术内透性多内透性思普拉丁输液,用于恶性多间皮瘤
Kenichi Okubo1, Hironori Ishibashi1, Ryo Wakejima1
1Department of Thoracic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
JTCVS open
|January 11, 2024
概括
这项研究表明,扩展性多切除术/脱皮术与高热性手术内化疗 (HIOC) 提供了恶性多间皮瘤 (MPM) 的良好生存率. 治疗是安全的,损伤有限,使其成为MPM患者的有希望的选择.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 药理动力学 药理动力学
背景情况:
- 恶性多层层层瘤 (MPM) 是一种具有攻击性的癌症,需要有效的治疗策略.
- 结合手术和化疗的多模式治疗是MPM管理的关键方法.
研究的目的:
- 评估扩展性多切除术/脱皮术 (P/D) 结合高热内科化疗 (HIOC) 的疗效和安全性,使用西斯治疗MPM.
- 分析的药理动力学,不良事件,以及接受这种联合治疗的MPM患者的生存结果.
主要方法:
- 五十三名MPM患者接受了延长的P/D和HIOC与西斯普拉丁 (80 mg/m2).
- 测量了的度在液和血清中;不良事件 (特别是脏) 和存活率被监测.
- 术后使用西斯普拉丁和佩米特雷克塞德进行全身化疗.
主要成果:
- 在所有患者中都实现了宏观的完全切除.
- 28%的西斯普拉丁留在胸腔中;血清白金水平达到0.91μg/mL的峰值.
- 11%的人患有肌素升高,4%需要脏替代疗法;30天死亡率为0%.
- 平均总生存期 (OS) 为52.4个月,无病生存期 (DFS) 为18.7个月.
- 第1A期患者的5年生存率为67.3%;第1B-3A期患者的5年生存率为50.1%.
结论:
- 延长P/D与基于西斯的HIOC是一种安全有效的多模式治疗MPM.
- 该方案表明有希望的生存结果,特别是在早期 (1A-3A) MPM.
- 组织学,病理阶段和多模式治疗被确定为OS的独立预后因素.
关键词:
急性脏损伤急性脏损伤是什么西斯普拉丁 (cisplatin) 是一种制剂.度 度 度 度 度 度 度超热性 术内 术内 肌内 肌内 化疗 化疗恶性多层层层层瘤.胸腔切除术/脱皮术是什么意思幸存率 幸存率 生存率更多相关视频
相关概念视频
Pleural Disorders: Types and Brief Description
209
The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
209
Pleura of the Lungs
1.9K
The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
1.9K
Pneumothorax-II
153
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
153
Pleural Effusion II: Symptoms and Management
179
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
179
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
201
Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
201
Flail Chest-II
174
Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:
Assessment:
1. Clinical Evaluation:
History:
174


