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常规的卵泡阶段卵巢刺激与低最佳响应者的黄质阶段刺激:一种随机对照试验

Jorge Suñol¹, Juan Carlos Castillo², José Antonio Ortiz²

¹Bernabeu Institute, Reproductive Medicine, Palma de Mallorca, Spain.

|January 11, 2024

概括

这项研究发现,在卵泡阶段刺激 (FPS) 和黄细胞阶段刺激 (LPS) 之间的卵细胞产量没有差异. 在这组患者中,叶阶段刺激与卵泡阶段刺激相比,没有改善卵细胞检索.

科学领域:

生殖内分泌学生殖内分泌学
在体外受精 (IVF)
卵巢刺激协议卵巢刺激协议

背景情况:

在试管婴儿中反应不佳的患者往往具有有限的卵细胞产量.
毛囊阶段刺激 (FPS) 和黄质阶段刺激 (LPS) 是两种不同的卵巢诱导协议.
与FPS相比,LPS在特定患者群体中的有效性仍然是一个研究领域.

研究的目的:

为了比较FPS和LPS在被归类为低于最佳反应的患者中检索的卵细胞数量.
评估二次结果,如第二阶段和受精卵细胞,FSH剂量和刺激持续时间.

主要方法:

一项前性随机交叉临床试验,涉及41名符合POSEIDON标准 (1b/2b) 的患者.
参与者接受了两次非连续的卵巢刺激,随机分配开始在卵泡或质阶段.
卵细胞产量 (积卵细胞复合体) 是主要的结果衡量标准.

主要成果:

在FPS和LPS组之间检索的累积卵细胞复合体的平均数量没有显著差异 (7.5 ± 4.6与7.0 ± 4.1).
同样,在两个刺激阶段 (5.4 ± 3.6与5.2 ± 2.8) 之间,获取的第二阶段卵子细胞的平均数量是可比的.
所有的二次结果测量也显示,FPS和LPS之间没有显著差异.

结论:

与卵泡阶段刺激相比,当周期在时间上相隔时,质阶段刺激不会提高低最佳响应者的卵细胞产量.
与FPS相比,LPS发病的时间似乎没有影响这个队列中的卵细胞检索结果.
目前的证据表明,FPS和LPS在非最佳反应者中产生类似的卵细胞数量.

关键词:

在这个过程中,IVF IVF.毛囊阶段刺激的激发.形阶段刺激的刺激.卵巢刺激卵巢刺激不理想的卵巢响应者

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