在患有单边海马硬化症的患者中,灰质体积的半球间不对称变化
Shunji Mugikura1, Naoko Mori2, Miyeong Gang3
1Department of Diagnostic Radiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Journal of clinical imaging science
|January 11, 2024
概括
这项研究表明,海马硬化症 (HS) 在受影响和未受影响的大脑半球中都会导致不对称的灰质体积 (GMV) 损失. 像海马体和基底前脑等关键区域在单边HS患者中显示出显著的GMV减少.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 大脑解剖学 大脑解剖学
背景情况:
- 单侧海马硬化症 (HS) 在灰质体积 (GMV) 中呈现复杂的半球间变化.
- 了解这些不对称的GMV变化对于诊断和管理HS至关重要.
研究的目的:
- 为了澄清单边HS.中半球间不对称的GMV变化.
- 为了比较与健康受试者相比,受影响和反侧面之间的GMV变化.
主要方法:
- 利用转基因病毒Z-score (Z-GMV) 来量化45名HS患者的区域转基因病毒变化,与30名对照人群相比.
- 采用了两个大脑图谱:解剖自动标记 (AAL) 58个区域/半球和解剖工具箱 78个区域/半球.
- 通过比较HS和反担保/非HS侧面之间的Z-GMV来确定不对称地减少的区域.
主要成果:
- 鉴定了7个和4个不对称地减少的区域使用AAL分别用于左手侧 (LHS) 和右手侧 (RHS) 的HS.
- 使用LHS和RHSHS的解剖学工具箱分别确定了17个和11个不对称地减少的区域.
- 半球中常见的受影响区域包括海马体,尾骨 (AAL),杏仁体,基底前脑 (BF) 和 thalamus (解剖学工具箱).
结论:
- Z-GMV有效地证明了在单边的HS中不对称地减少了GMV区域.
- 海马和海马外区域,包括基底前脑 (BF),在单边的HS中在两个半球中都受到持续影响.
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