循环RNA:潜在的生物标记物和自身免疫性疾病的治疗点
Ren-Jie Zhao1, Wan-Ying Zhang1, Xing-Xing Fan1
1Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau(SAR), China.
Heliyon
|January 11, 2024
概括
循环RNAs (circRNAs) 在自身免疫性疾病中表现异常,具有作为诊断生物标志物和治疗点的潜力. 本综述探讨了它们在类风湿性关节炎和狼等疾病中的作用.
科学领域:
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 自免疫性疾病需要早期诊断才能有效治疗,但早期症状往往模仿炎症状况,使诊断复杂化.
- 循环RNA (circRNAs) 是一种新型内源RNA,在微RNA (miRNA) 泡和蛋白质编码中发挥作用.
- 在自身免疫性疾病患者的液体活检中观察到异常的circRNA表达,这表明它们具有作为生物标志物的潜力.
研究的目的:
- 审查最近在理解circRNAs在自身免疫性疾病病变发生中的作用方面的进展.
- 探索circRNAs作为自身免疫疾病的诊断和预后生物标志物的潜力.
- 讨论在自身免疫性疾病中准circRNAs的治疗含义.
主要方法:
- 在自身免疫性疾病中调查circRNAs的研究的文献综述.
- 在液体活检样本中分析circRNA表达模式.
- 检查circRNA功能,包括miRNA海绵和蛋白质相互作用.
主要成果:
- 在各种自身免疫性疾病中,circRNAs的调节失调,包括类风湿性关节炎,全身性红斑狼,多发性硬化症和1型糖尿病.
- 血,唾液和尿液中的改变circRNA表达表明它们作为非侵入性生物标志物的潜力.
- circRNAs在自身免疫性疾病的发病过程中起着重要的作用.
结论:
- circRNAs代表了早期诊断和自身免疫性疾病的预后有前途的生物标志物.
- circRNAs有可能成为新的治疗点,研究过度表达或耗尽等策略.
- 对circRNA机制的进一步研究可以促进自身免疫性疾病的管理.
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