在澳大利亚的毒品检查服务中发现了三种意想不到的新型精神活性物质
Jess L Algar1,2, Douglas J Lawes1, Adam J Carroll1
1Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
Drug testing and analysis
|January 11, 2024
概括
药物检查服务发现了三个意想不到的新型精神活性物质,不符合客户的预期. 这凸显了药品检查在监控不受管制的药品市场和确保公共安全方面发挥的关键作用.
科学领域:
- 法医化学 法医化学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 药物检查服务是减少危害的重要工具,使个人能够验证物质含量.
- 澳大利亚的CanTEST健康和药物检查服务是全国第一个提供此类分析和建议的固定设施.
- 该服务旨在提供有关非法物质的准确信息,并促进更安全的消费做法.
研究的目的:
- 为了识别和描述向药物检查服务提交的三个不符合客户期望的物质.
- 调查药物检查在未经监管的药物市场中检测新型精神活性物质的有用性.
- 提供关于新发现的精神活性化合物的详细化学和结构信息.
主要方法:
- 在现场对三个客户提交的样本进行假定药物检查.
- 先进的分析技术包括核磁共振 (NMR) 谱学,高分辨率气体染色学-电子电离-质谱学 (HRGC-EI-MS) 和液体染色学-电子喷射电离-质谱学 (LC-ESI-MS) 进行最终识别.
- 结构阐明和未知化合物的表征.
主要成果:
- 三个样本,预计是4-甲基化物 (4F-MPH),甲索胺 (MXE) 和3-甲基甲胺 (3-MMC),在详细分析后发现是不同的物质.
- 确定的化合物是4--α-pyrrolidinoisohexanophenone (4F-α-PiHP),1-(4-fluorobenzyl) -4-methylpiperazine (4F-MBZP),以及N-propyl-1,2-diphenylethylamine (propylphenidine) 这四种化合物.
- 这些已识别的物质以前没有在科学文献中被描述为新的精神活性物质.
结论:
- 药物检查服务可以有效地识别在不受监管的药物市场上流通的意想不到和新型的精神活性物质.
- 这三种未知的化合物的快速识别强调了先进的分析能力在药物检查中的重要性.
- 这项研究表明药物检查作为新兴合成药物的监控工具的价值,有助于公共健康和安全.
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