肝细胞生长因子作为亚临床动脉样硬化的指标
Philip Sommer1,2, Michael Schreinlechner1, Maria Noflatscher1
1Department of Internal Medicine III (Cardiology and Angiology), Medical University of Innsbruck, Austria.
VASA. Zeitschrift fur Gefasskrankheiten
|January 11, 2024
概括
肝细胞生长因子 (HGF) 与较高的动脉样硬化斑块体积显著相关. 这一发现表明HGF可能作为动脉样硬化的潜在生物标志物,有助于早期检测和风险评估.
科学领域:
- 心血管医学 心血管医学
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 肝细胞生长因子 (HGF) 是由介质细胞产生的一种细胞因子.
- 在内皮损伤后,HGF被释放到循环中,特别是来自氧化低密度脂蛋白 (LDL).
- 目前正在研究HGF作为动脉样硬化的潜在临床生物标志物.
研究的目的:
- 调查血HGF水平与动脉样硬化斑块负担之间的关联.
- 评估HGF作为亚临床和临床动脉样硬化的潜在生物标志物.
主要方法:
- 一项观察性单中心队列研究包括171名患有心血管风险因素或已确定的心血管疾病 (CVD) 的患者.
- 进行了动脉和大腿动脉的3D斑块体积测量.
- 测量了血HGF,高灵敏性C反应蛋白和LDL胆固醇水平.
主要成果:
- HGF与总斑块体积 (TPV) 有显著的正相关性 (r=0.48;p<0.001).
- 接收器操作特征 (ROC) 分析表明,HGF可以预测高TPV (AUC=0.68) 和心血管疾病 (AUC=0.65) 的存在.
- 在特定的切线点上,高基显示出高TPV的灵敏度为78%,CVD的灵敏度为77%.
结论:
- 血HGF水平升高与动脉样硬化斑块体积增加有关.
- HGF显示出作为评估动脉样硬化负担和心血管疾病风险的生物标志物的潜力.
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