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一种贝叶斯函数式方法来测试生命过程流行病学模型的连续时间
Julien Bodelet1,2, Cecilia Potente1,3, Guillaume Blanc1
1Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland.
International journal of epidemiology
|January 11, 2024
概括
功能相关生命周期模型 (fRLM) 从重复风险测量中准确识别生命周期流行病学模型. 这种方法增强了对疾病发展中的关键和敏感时期的理解,例如身体质量指数 (BMI).
科学领域:
- 生命过程流行病学的流行病学.
- 生物统计学 生物统计学
- 基因组学就是基因组学.
背景情况:
- 生命过程流行病学研究了整个生命周期的风险和健康.
- 当前的模型经常使用离散时间假设,可能错过了连续的风险过程.
研究的目的:
- 介绍持续风险过程的功能相关生命周期模型 (fRLM).
- 开发一种方法,将概率分配给生命过程流行病学模型 (关键,敏感,积累).
主要方法:
- 在fRLM中,离散风险指标被视为未观察到的连续过程.
- 一个测试程序将概率分配给概念生命周期模型.
- 通过模拟进行评估,并应用于BMI和与疾病相关的mRNA-seq数据.
主要成果:
- fRLM正确识别了3-5个风险评估和400个受试者的生命过程模型.
- 慢性病与关键期过程相关.
- 与敏感周期机制相关的炎症和乳腺癌.
结论:
- fRLM准确地将重复的风险测量模型作为连续的过程.
- 为常见的生命过程流行病学模型提供可靠的概率.
- 在公开可用的软件中实现,用于更广泛的应用.
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