补充剂抑制剂在肌痛性肌痛症中的新用途 - - 两份病例报告
Sean Zadeh1, Hayley Price1, Reed Drews2
1Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, USA.
Muscle & nerve
|January 11, 2024
概括
像eculizumab这样的补充抑制剂有效地治疗了两名患者的免疫检查点抑制剂 (ICI) 诱导的严重肌痛性肌痛症 (MG). 一名患者经历了预防性益处,这表明有可能预防与免疫相关的不良反应 (irAEs).
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 骨髓灰质炎 (MG) 是一种罕见但严重的与免疫相关的不良反应 (irAE),与免疫检查点抑制剂 (ICI) 治疗相关.
- 补充C5抑制剂已经证明在治疗乙胆受体抗体 (AChR ab) 阳性通用MG的治疗中具有有效性.
研究的目的:
- 描述C5补充抑制剂 (eculizumab/ravulizumab) 在接受同时服用pembrolizumab的MG患者中的使用.
- 评估补充剂抑制在管理ICI诱导的MG中的疗效和潜在的预防作用.
主要方法:
- 两名患者的病历的回顾性审查.
- 对接受布罗利祖马布和C5补充抑制剂的患者中肌痛性肌痛症和其他irrAEs的治疗结果的分析.
主要成果:
- 埃奎利祖马布,其次是拉武利祖马布,改善了ICI诱导的ACHRab-阳性MG,该患者还患有肌肉炎和心肌炎.
- 在第二个患有胸腺瘤相关MG的患者中,eculizumab在对转移性默克尔细胞癌的pembrolizumab治疗期间保持了MG稳定性,可能会对进一步的irAEs产生预防作用.
结论:
- 补充C5抑制剂 (eculizumab/ravulizumab) 可以有效地管理免疫检查点抑制剂诱导的严重肌痛性肌痛症.
- 在接受ICI治疗的患有先前自身免疫疾病的患者中,eculizumab可能在预防与免疫相关的不良事件方面发挥预防作用.
- 需要进一步研究以了解补充抑制对ICI治疗结果和irAEs的影响.
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