儿童体育活动和青春期时间:LEGACY女孩研究的结果
Rebecca D Kehm1, Julia A Knight2,3, Lauren C Houghton1,4
1Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
International journal of epidemiology
|January 11, 2024
概括
幼儿时期的体力活动可能会延迟乳腺癌家族史的女孩的larche. 在所有女孩中,中年儿童的体力活动与晚期初潮有关,而不依赖于体重指数.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 关于儿童早期体育活动与女孩青春期的时间之间的关联的研究有限.
- 了解这种关系对于识别影响青春期发育的潜在可修改因素至关重要.
研究的目的:
- 调查早期和中年儿童体育活动 (PA) 与女孩青春期事件 (thelarche, pubarche, menarche) 的时间之间的联系.
- 通过乳腺癌家族史 (BCFH) 和通过体重指数z-score (BMIZ) 的调解来检查潜在的效果修饰.
主要方法:
- 利用了LEGACY女孩研究 (n=984) 的数据,这是一个北美队列,对BCFH的女孩进行了丰富.
- 采用间隔审查的韦布尔生存回归模型,调整社会人口统计因素.
- 在幼儿时期 (3-5岁) 评估PA,在中年阶段 (7-9岁) 组织PA,使用母亲报告的问卷.
主要成果:
- 在BCFH (aHR=0.39) 的女孩中,更高的早期儿童PA与晚期的larche有关,但在没有BCFH的女孩中并非如此.
- 在中年儿童期有组织的更高的PA与所有女孩的晚期初潮有关 (aHR=0.70),不管BCFH.
- 考虑到BMIZ调解后,这些关联仍然存在.
结论:
- 在乳腺癌家族史的女孩中,幼儿时期的体力活动可能与延迟的腹痛有关.
- 儿童中期的体力活动与所有女孩的初潮晚期有关,支持其在青春期计时中的作用.
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