偏性半头的流行病学和临床特征:系统性审查和元分析
Mikkel J Henningsen1,2, Johanne G Larsen1,2, William K Karlsson1,2
1Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Headache
|January 11, 2024
概括
发性半头痛是一种罕见的头痛疾病,在0.3%的三级护理患者中发现. 它在一般人群中的患病率尚不清楚,尽管眼和结膜注射是常见的症状.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 头痛 医学 医学 医学
背景情况:
- 发性半头痛是一种罕见的三角形自主性脑膜痛,其特点是严重的头痛发作,自主性症状和对印莫他辛的反应.
- 在一般和三级护理人群中, Paroxysmal hemicrania 的流行病学负担和临床特征频率尚未得到充分确立.
研究的目的:
- 为了确定成年人中 Paroxysmal hemicrania 的患病率和相对频率.
- 为了确定与偏性半脑相关的临床特征.
主要方法:
- 对PubMed和Embase (1988-2023) 的系统文献搜索进行了观察性研究.
- 进行了流行率和相对频率数据的元分析,并使用Joanna Briggs Institute标准评估偏差风险.
- 关于PROSPERO的预先注册的研究 (CRD42023391127).
主要成果:
- 17项基于临床的研究和1项基于人群的研究符合纳入标准,总体偏差风险很高.
- 在第三级护理的头痛患者中, Paroxysmal hemicrania 的相对频率为0.3% (95% CI,0.2%-0.5%),具有显著的异质性.
- 在一般人口样本中没有发现任何病例;常见的症状包括眼 (77.3%) 和结膜注射 (75.0%).
结论:
- 发性半脑似乎是成年人寻求在第三级护理机构评估头痛的罕见情况.
- 在一般人群中的患病率仍未确定.
- 需要对 Paroxysmal Hemicrania 的临床特征进行进一步的研究.
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