在金属酶和抗铜疗法中的-铜对立性
Biplab K Maiti1, Isabel Moura2, José J G Moura2
1Department of Chemistry, School of sciences, Cluster University of Jammu, Canal Road, Jammu, 180001, India.
Chembiochem : a European journal of chemical biology
|January 11, 2024
概括
在金属蛋白和反动物中观察到的-铜对抗性,涉及四聚酸盐 (TTM) 封存铜. 这种互动激发了TTM的灵感.
科学领域:
- 生物化学 生物化学
- 金属蛋白化学 金属蛋白化学
- 医学化学 医学化学
背景情况:
- -铜 (Mo-Cu) 反对是通过"Mo-S-Cu"结构单元进行调解的.
- 这种对抗性在金属蛋白中得到体现,例如/铜-CO脱酶 (Mo/Cu-CODH) 和/铜色蛋白 (Mo/Cu-ORP).
- 自然发生的Mo-Cu对抗性首次在反动物中被发现,其中酸盐转化为四基酸盐 (TTM),导致铜缺乏.
研究的目的:
- 探索生物系统中Mo-Cu对抗的结构功能关系.
- 将金属蛋白中的Mo-Cu对抗性的理解与其治疗潜力联系起来.
- 审查TTM作为抗铜治疗剂的应用,用于治疗依赖铜的疾病.
主要方法:
- 关于金属蛋白中Mo-Cu对抗性的现有文献的综述.
- 生物学案例研究的分析,包括Mo/Cu-CODH和Mo/Cu-ORP.
- 检查TTM形成的机制及其与生物系统中铜的相互作用.
主要成果:
- 在金属蛋白和生物铜恒温中,Mo-Cu对抗起着至关重要的作用.
- 在反动物中,TTM的形成显示出一种天然的铜封存机制.
- 由于TTM能够形成生物学上不可用的Mo/S/Cu集群,这凸显了其作为铜分离剂的潜力.
结论:
- Mo-Cu对抗是一种重要的生物相互作用,对铜的恒温有影响.
- 对金属蛋白中Mo-Cu对抗性的研究为治疗策略提供了洞察力.
- 四聚酸 (TTM) 显示为治疗威尔逊病和癌症等与铜有关的疾病的治疗药物.
相关概念视频
Extraction: Advanced Methods
447
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
447
Combined Effects of Drugs: Antagonism
8.5K
The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
8.5K
Antidotes
649
Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
649
Electron Transport Chain: Complex I and II
13.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
13.4K
Drugs that Stabilize Microtubules
2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
Mania and Antimanic Drugs: Overview
184
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
184


