血清肌氨酸参考间隔的数据挖掘:基于Q值的膜过率估计方程的改进
Yao Ma1, Zhenzhu Yong1, Lu Wei1
1Division of Nephrology, Department of Geriatrics, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, P.R. China.
Clinical chemistry and laboratory medicine
|January 11, 2024
概括
这项研究建立了中国血清肌氨酸的参考间隔和Q值,提高了中国人群中质过率 (GFR) 估计的准确性. 新的值增强了GFR方程,以便更好地临床应用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 临床化学 临床化学
- 生物统计学 生物统计学
背景情况:
- 使用重新缩放的血清肌素 (SCr/Q) 的淋巴膜过率 (GFR) 估计方程提供了更好的性能.
- Q表示特定年龄和性别的健康人群的中位数SCr.
- 缺乏有关中国人口特异性Q值的SCr.数据.
研究的目的:
- 开发中国年龄和性别特定的参考间隔 (RIs) 和血清肌素 (SCr) 的Q值.
- 为了验证包含这些新的中国Q值的GFR估计方程.
主要方法:
- 包括117,345名成年人来确定RI和Q值,以及3,692名参与者与参考GFR (rGFR) 进行验证.
- 通过决策树方法确定年龄分区;用refineR算法计算RI和中位数.
- 评估全年龄谱 (FAS) 和欧洲功能联盟 (EKFC) 方程与调整的Q值,评估偏差,精度 (IQR) 和准确性 (P20,P30).
主要成果:
- 在不同年龄和性别群体中为SCr建立了中国RI.
- 确定的中国Q值:男性为73.82μmol/L,女性为53.80μmol/L.
- 经过验证的方程显示偏差减少,精度和准确性提高,以及更好的GFR类别协议.
结论:
- 成功确定了中国年龄和性别特定的参考间隔和血清肌氨酸的Q值.
- 可调整的Q值为获得有效的GFR估计方程提供了一种有效的方法.
- 这些发现支持了中国人口中GFR估计的改进.
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