患有肺部感染的儿童的炎症反弹和感染后炎症反应:单中心回顾性研究
Clément Poirault1, Alice Hadchouel1, Charlotte Roy1
1Department of Pediatric Pulmonology and Allergology, University Hospital Necker-Enfants Malades, AP-HP, Paris, France.
Pediatric pulmonology
|January 11, 2024
概括
在38%患有膜感染 (PI) 的儿童中发生了炎症反弹. 这表明,如果在第二到第五天之间早期给予皮质激素,皮质类固醇可能对PI的儿童有益.
科学领域:
- 儿童传染病 儿童传染病
- 关键护理医学 关键护理医学
- 炎症研究 炎症研究
背景情况:
- 胸腔炎症是儿科胸腔感染 (PI) 的核心.
- 皮质类固醇治疗正在研究PI,但最佳时间和患者选择尚不清楚.
- 研究儿科PI的炎症轨迹对于治疗优化至关重要.
研究的目的:
- 分析被诊断患有膜感染 (PI) 的儿童的炎症模式.
- 确定与疾病进展和治疗反应相关的因素.
- 为了告知儿童PI.潜在的皮质类固醇干预的时间.
主要方法:
- 儿科PI病例的回顾性单中心研究 (3个月至17年,11个月).
- 包括患有由Streptococcus pyogenes,Streptococcus pneumoniae和Staphylococcus aureus引起的PI的患者.
- 炎症反弹被定义为C-反应蛋白 (CRP) 增加≥50 mg/L,在最初降低≥50 mg/L后.
主要成果:
- 分析了53个儿科PI病例.
- 20名患者 (38%) 观察到炎症反弹,特别是那些患有S. pyogenes. 的患者.
- 经历炎症反弹的患者发烧持续时间长,住院时间更长.
结论:
- 近40%的儿科PI患者表现出炎症反弹.
- 这种反弹可能代表了早期的感染后炎症反应.
- 皮质类固醇可能在儿科PI中最有效,如果在早期 (2-5天) 服用.
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