肥胖和有害的酒精消费是2型糖尿病疾病管理计划中晚期肝病的预测因素
Maurice Michel1,2, Michelle Doll1,2, Nastasia Albert1,2
1Metabolic Liver Research Program, I. Department of Medicine, University Medical Centre Mainz, Mainz, Germany.
United European gastroenterology journal
|January 11, 2024
概括
德国2型糖尿病患者的肝纤维化和肝硬化率很高. 肥胖和滥用酒精显著增加这些风险,强调了糖尿病管理计划中早期查的必要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 主要护理医学 医疗保健
背景情况:
- 2型糖尿病 (T2DM) 是晚期肝病的重要危险因素.
- 评估T2DM患者肝纤维化和肝硬化患病率对于疾病管理至关重要.
研究的目的:
- 为了确定肝纤维化和肝硬化在德国T2DM初级保健患者的患病率.
- 为了确定与该人群中晚期肝病相关的风险因素.
主要方法:
- 在德国初级保健中心对175名T2DM患者进行前性队列研究.
- 通过使用振动控制的短暂弹性图谱进行脂肪性肝病,纤维化和肝硬化的非侵入性评估.
- 多变量后勤回归和AUDIT调查问卷用于风险因素分析,包括肥胖和酒精消费.
主要成果:
- 脂肪性肝病的患病率为77.1%,纤维化为42.3%,肝硬化为12.0%.
- 肥胖 (OR 5.198) 和有害的酒精消费 (OR 5.615) 与分别纤维化和肝硬化增加的几率显著相关.
- 在队列中的8.0%和肝硬化患者中的20.0%观察到有害的酒精消费.
结论:
- 肝纤维化和肝硬化在德国糖尿病疾病管理计划 (DMP) 中的T2DM患者中存在很高的患病率.
- 肥胖和有害的酒精消费是该队列中晚期肝病的关键风险因素.
- 将高级肝病查整合到T2DM管理计划中可以减轻与肝脏有关的并发症.
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