心声谱与心脏MRI对比,用于测量癌症和疑似心脏毒性患者的左心室射出分数
Muhummad Sohaib Nazir1, Joseph Okafor1, Theodore Murphy1
1From the Cardio-Oncology Service (M.S.N., T.M., M.S.A., S.R., S.D.R., A.R.L.), Department of Echocardiography (J.O., R.K.), and Cardiovascular Magnetic Resonance Unit (S. Prasad, R.M., D.J.P., A.J.B.), Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; School of Biomedical Engineering and Imaging Sciences, King's College London, Guy's and St Thomas' Hospital, London SE1 7EU, United Kingdom (M.S.N., A.C., S. Plein); and National Heart & Lung Institute, Imperial College London, London, United Kingdom (S.D.R., S. Prasad, R.M., D.J.P., A.J.B., A.R.L.).
三维回声心脏图提供了比二维回声心脏图更好的协议,用于测量癌症患者的左心室喷射率 (LVEF),提高心脏毒性检测的准确性.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 精确评估左心室喷射率 (LVEF) 对于检测癌症患者的心脏毒性至关重要.
- 心声图和心脏MRI通常用于LVEF评估,但它们在这个人群中的一致性需要进一步调查.
研究的目的:
- 为了比较癌症患者的心声心电图 (2D和3D) 和心脏MRI之间的LVEF测量.
- 评估测量差异对心脏毒性检测和临床决策的影响.
主要方法:
- 一项前性观察队列研究,涉及745名癌症患者,他们在同一天接受2D心声学和心脏MRI.
- 74名患者的小组也接受了3D心声回声.
- 用布兰德-阿尔特曼分析来评估在相关心脏毒性值处的模式之间的一致性.
主要成果:
- 二维回声心脏图显示,心脏MRI的平均偏差为-3.7%,一致性极限为-18.5%至11.1%.
- 心脏毒性检测的不一致 (LVEF <50%) 发生在9.3%的参与者2D心声谱与心脏MRI相比.
- 与二维回声心脏图相比,三维回声心脏图显示出与心脏MRI的更好一致 (平均偏差-1.6%,LOA-13.9%至10.7%).
结论:
- 在癌症患者中,二维回声心脏图显示LVEF测量与心脏MRI相比具有显著的变异性,可能错误地分类心脏毒性.
- 三维回声心电图为LVEF评估提供了与心脏MRI的改进协议.
- 在这个患者群体中,三维回声心脏图像被推为首选的第一线成像方法,用于LVEF评估.
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