在酒精使用障碍中,执行大脑-小脑功能连接受损
Laura C Rice1, Mackenzie T Langan1, Dominic T Cheng1
1Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Alcohol, clinical & experimental research
|January 11, 2024
概括
患有酒精使用障碍 (AUD) 的个体在前对对面网络 (FPN) 中表现出功能连接性 (FC) 的减少. 这种减少的FPN连接性与AUD中较差的执行功能性能有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 酒精使用障碍 (AUD) 是一个日益严重的全球健康问题,影响着数百万人.
- 小脑在执行控制中的作用和酒精的影响强调了在AUD中研究大脑-小脑功能连接 (FC) 的必要性.
- 很少有研究研究小脑参与与AUD相关的功能网络.
研究的目的:
- 为了比较AUD和控制 (CTL) 的戒断成年人之间的静止状态功能连接 (FC) 模式.
- 调查大脑-小脑FC的群体差异,特别是前端对象/执行控制网络 (FPN) 中的差异.
主要方法:
- 28名参与者 (AUD和CTL) 接受了静止状态的功能磁共振成像 (rsfMRI).
- 多变量模式分析 (MVPA) 确定了群体之间存在显著FC差异的区域.
- 基于种子的分析和与威斯康星州卡片排序测试 (WCST) 的相关性评估了FC的方向性,范围和执行职能关联.
主要成果:
- 在FPN,腹部注意网络和默认模式网络的节点中发现了FC的显著群体差异.
- 与对照组相比,AUD参与者在脑小脑FPN内显著减少了FC.
- 在AUD中,特定FPN集群 (左侧Crus II,右额叶皮层) 之间的FC强度与WCST性能呈正相关性.
结论:
- 患有AUD的个体表现出前端对象网络 (FPN) 的参与减少.
- 在FPN中的FC强度与AUD中的执行功能性能 (WCST) 有积极的关联.
- 长期重度饮酒似乎会改变大脑-小脑FC,特别是在执行功能网络中.
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