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相关概念视频

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
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甲酸盐暴露与青春期发育之间的关联

Mi Ra Kim1, Mo Kyung Jung2, Hye Mi Jee2

  • 1Department of Pediatrics, CHA Ilsan Medical Center, CHA University School of Medicine, Goyang, Korea.

European journal of pediatrics
|January 11, 2024
PubMed
概括

暴露于甲酸盐可能会阻碍男孩的青春期发育,特别是高分子量甲酸盐 (HMWP). 相比之下,低分子量甲酸盐 (LMWP) 与女孩的晚年青春期有关,这表明性别特异性影响.

关键词:
雌二醇是雌二醇的一种药物.一个女人,一个女人.男人 男人 男人 男人 男人甲酸是一种甲酸.青春期 青春期 青春期测试激素 测试激素是什么

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科学领域:

  • 内分泌学和毒理学.
  • 环境健康 环境健康
  • 儿科发展 儿科发展

背景情况:

  • 酸盐是具有已知的抗雄激素作用的化学物质.
  • 之前对儿童的甲酸盐暴露和青春期发育的研究表明了不一致的结果.
  • 区分高分子量甲酸盐 (HMWP) 和低分子量甲酸盐 (LMWP) 的作用至关重要.

研究的目的:

  • 调查韩国儿童甲酸盐暴露与青春期发育之间的关联.
  • 确定HMWP和LMWP是否对男孩和女孩的青春期发育有不同的影响.

主要方法:

  • 在236名男孩和202名10-12岁的女孩身上测量了尿液中甲酸代谢物 (4HMWPs,3LMWPs).
  • 青春期的阶段是由父母自我报告的.
  • 分析了性类固醇水平 (和雌激素).
  • 使用了通用线性回归,调整了年龄,BMI z-score 和出生史.

主要成果:

  • 在男孩中,高水平的HMWP和LMWP与青春期相反相关.
  • 在男孩中,更高的HMWP水平也与显著降低的丸激素水平有关.
  • 在女孩中,较高的LMWP水平与晚期青春期相显著相关,但与HMWP或雌激素水平没有发现任何关联.

结论:

  • 酸盐暴露,特别是HMWP,可能会对男性青春期发育产生负面影响.
  • LMWP暴露显示了与女孩加快青春期发育的潜在关联.
  • 需要进一步的研究来证实甲酸盐暴露与女孩青春期发育之间的关系.