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通过实时相对照MRI研究从童年到成年时期的CSF和静脉血流

Prativa Sahoo¹, Jost M Kollmeier², Nora Wenkel³

¹Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Robert Koch Street 40, 37075, Göttingen, Germany. psahoo@gwdg.de.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

|January 11, 2024

概括

实时相对照MRI显示了健康个体中脑脊液 (CSF) 和静脉流量的年龄相关变化. 这些发现确定了正常流量参数,这对于诊断儿科头症和其他CSF循环障碍至关重要.

科学领域:

神经成像是一种神经成像.
流体动力学流体动力学
儿科生理学儿科生理学

背景情况:

脑脊液 (CSF) 和静脉流动力学对于神经健康至关重要.
了解正常流量参数对于诊断诸如水头等疾病至关重要,特别是在儿科患者群体中.
实时相对比 (RT-PC) 磁共振成像 (MRI) 提供了对这些流体系统的体内洞察.

研究的目的:

使用RT-PCMRI在健康受试者中确定CSF和静脉流的参考值.
在5-40岁的个体中确定这些流量参数的年龄依赖.
为评估CSF循环病态提供基准.

主要方法:

在44名健康志愿者 (5-40岁) 上进行了RT-PC MRI.
在水道 (Aqd),宫 (C3) 和腰部 (L3) 水平上量化了CSF流量.
静脉流量测量在外围静脉,内静脉和下腔静脉,分析峰值速度,净流量和脉动性.

主要成果:

在成年志愿者中没有观察到流量参数的显著变化.
儿科受试者在所有测量脊柱水平 (Aqd,C3,L3) 上显示,脑脊液净流量和脉动性随年龄而显著下降.
静脉流量参数在C3表现出与年龄相关的显著下降,在L3.3表现出变量的变化.

结论:

脑脊液和静脉流量参数受解剖位置和年龄的影响.
这项研究成功地描述了5岁至40岁大脑和脊髓液动态的与年龄相关的变化.
RT-PC MRI的临床应用可以增强对单个CSF流动病态的理解和诊断.

关键词:

与年龄相关的流量变化.在CSF的动态.儿童时代的水头.实时相位对比MRI实时相位对比MRI 静脉流动是一种静脉流动.

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