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康宁皮里丁A和B,是来自Trichoderma koningiopsis SC-5真菌的两种含的多基基

Weiwei Peng^1,2, Qi Huang^1,3, Xin Ke^1,2

¹Xiangya School of Pharmaceutical Sciences, Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, 410013, People's Republic of China.

Natural products and bioprospecting

|January 11, 2024

概括

从Trichoderma koningiopsis真菌中发现了两种新型的koninginin衍生物,koningipyridines A和B. 这些新型化合物具有独特的化环系统,并对抗微生物和细胞毒性活动进行了评估.

科学领域:

自然产品化学自然产品化学
菌类学菌类学是指菌类学.
有机化学有机化学

背景情况:

像Trichoderma koningiopsis这样的内菌是生物活性天然产品的丰富来源.
康宁宁衍生物因其生物活性而闻名,但不断寻找新的结构类.

研究的目的:

从Trichoderma koningiopsis SC-5中分离和描述新的化合物.
研究孤立自然产品的结构新性和潜在生物活性.

主要方法:

使用乙烯酸乙烯提取真菌生物质和隔离二次代谢产物.
使用1D/2D NMR,HRESIMS和计算方法 (13C NMR,ECD) 阐明新型化合物的结构.
查抗菌活性针对金黄色葡萄球菌,MRSA和大肠杆菌,以及针对A549,Hela和HepG2癌细胞系的细胞毒性.

主要成果:

隔离了两种新的koninginin衍生物,koningipyridines A和B,以及四种已知的化合物.
康宁氨酸A呈现出前所未有的五环基骨架 (6/6/5/6/5 化环) 和氨酸核,代表了第一种含的koninginin类型天然产品.
康林皮里丁B具有独特的6/6/5二皮里丁骨架,可能作为康林皮里丁A的生物合成前体.

结论:

这项研究成功地发现了来自内生菌的独特结构特征的新型koninginin衍生物.
这些发现扩大了国王宁类自然产品的化学多样性,并为进一步研究它们的生物合成途径和药理潜力提供了线索.

关键词:

细胞毒性活动的细胞毒性.内部植物性真菌内部植物性真菌科宁基皮里丁 (Koningipyridine) 是一种酸盐.二次代谢产物二次代谢产物三 ?? 虫 (Trichoderma koningiopsis) 是一种有毒的植物.

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