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微RNA和心血管疾病风险

Charles D Searles¹

¹Emory University School of Medicine and Atlanta VA Health Care System, 1670 Clairmont Road, Decatur, GA, 30033, USA. csearle@emory.edu.

Current cardiology reports

|January 11, 2024

概括

细胞外微RNAs (miRNAs) 显示为心血管疾病风险和预后的非侵入性生物标志物具有前途. 然而,需要标准化的方法来提高临床应用的可复制性.

科学领域:

心血管生物学心血管生物学
分子诊断学分子诊断
生物标志物发现发现

背景情况:

微RNA (miRNA) 是短的,非编码的RNA,在心血管生物学中至关重要.
变化的细胞内miRNA表达与心血管疾病 (CVD) 的发展有关.
血液中的细胞外miRNA具有作为非侵入性心血管疾病生物标志物的潜力.

研究的目的:

审查目前关于miRNAs作为心血管疾病风险和预后生物标志物的知识.
总结细胞外miRNAs在评估心血管疾病风险方面的潜力.
突出miRNA生物标志物应用的挑战和未来方向.

主要方法:

对研究细胞外miRNA和心血管疾病的文献综述.
分析miRNA配置文件与心血管疾病风险分层之间的关联.
评估影响可重现性的方法因素.

主要成果:

许多研究将细胞外miRNA配置文件与心血管疾病联系起来.
细胞外miRNAs显示了潜在的心血管疾病风险分层.
由于方法上的差异,可复制性差,阻碍了临床应用.

结论:

循环的细胞外miRNAs是心血管疾病的有希望的生物标志物.
标准化方法对于可靠的临床实施至关重要.
为了验证miRNA生物标志物,需要进行更大规模,更精心设计的研究.

关键词:

节律失常 (arrhythmia) 是一种心律失常.生物标志物生物标志物心血管疾病是什么心血管疾病冠状动脉疾病是一种冠状动脉疾病.细胞外的微型RNA.心脏衰竭是因为心脏衰竭.这是一个微型RNA.

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