传染病感染和慢性肌肉骨疼痛
Diana L Zychowski1, Carolina Alvarez2, Haley Abernathy3
1Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill.
JAMA network open
|January 11, 2024
概括
传播的疾病,如耳病和病,与慢性肌肉骨疼痛或骨关节炎无关. 然而,银河糖-α-1,3-银河糖 (α-gal) 综合征可能与膝盖疼痛有关.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 除了莱姆病之外,传播的疾病 (TBD),包括斑点性发烧 (Rickettsiosis),ehrlichiosis和银河糖-α-1,3-银河糖 (α-gal) 综合征,代表着日益严重的公共卫生问题.
- 虽然长期出现埃里希亚菌或瑞克菌感染的并发症很少见,但肌肉骨症状经常与过去的暴露有关.
研究的目的:
- 研究先前暴露于TBD和肌肉骨症状的发展之间的潜在关系.
- 评估TBD血清阳性和放射性骨关节炎之间的关联.
主要方法:
- 来自约翰斯顿县骨关节炎 (JoCo OA) 项目的血清样本的分析,这是一项基于人口的纵向研究.
- 对埃里希亚IgG,瑞凯IgG和α-galIgE抗体进行血清检测.
- 采用多变量模型来确定TBD血清阳性与肌肉骨症状 (包括膝关节关节炎) 之间的关联.
主要成果:
- 埃里希亚IgG,里克特西亚IgG和α-galIgE的患病率分别为8.6%,17.1%和19.6%.
- 较高的α-gal IgE水平与膝盖疼痛,疼痛或硬有关 (平均比率为1.30).
- 没有发现Rickettsia,Ehrlichia或α-gal血清阳性与症状放射性膝关节骨关节炎之间的显著关联.
结论:
- 这项研究发现,埃里希亚菌或瑞克菌的血清阳性与慢性肌肉骨症状或骨关节炎之间没有联系.
- 进一步的研究是有必要的,以了解α-gal综合征的机制,并制定策略,以尽量减少人类的接触.
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