用户体验测试用于选择基本药物的证据决策框架
Thomas Piggott1,2, Lorenzo Moja3, Carlos A Cuello Garcia1
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
PLOS global public health
|January 11, 2024
概括
基本药物清单 (EML) 可以使用证据到决策 (EtD) 框架和视觉摘要来加强. 这些工具提高了透明度和效率,为全球卫生保健提供优先级的药物.
科学领域:
- 卫生政策 卫生政策
- 证据综合 证据综合
- 卫生经济学 卫生经济学
背景情况:
- 基本药物清单 (EML) 对于全球药物优先级的制定至关重要,被世界卫生组织和130多个国家使用.
- 世界卫生组织 (WHO) 关于选择和使用基本药物的专家委员会采用类似于GRADE证据决策 (EtD) 框架的标准.
- 提高EML选择中的透明度和证据整合对于实现全民健康覆盖至关重要.
研究的目的:
- 探索证据决策 (EtD) 框架和视觉摘要作为基本药物清单 (EML) 应用程序的补充工具的实用性.
- 评估用户体验,并确定将EtD框架和视觉摘要集成到EML选择过程中的改进.
主要方法:
- 用户体验测试采访与主要EML利益相关者 (13名受访者) 使用莫维尔蜂模型进行了采访.
- 对17个采访成绩单进行了主题分析,以代地完善EtD框架和视觉摘要.
- 两个特定的EML应用 (长效胰岛素类似物和免疫检查点抑制剂) 被用作案例研究.
主要成果:
- 利益相关者发现EtD框架和视觉摘要对传统的EML应用有用,可查找和补充.
- 这些工具被认为可以提高EML委员会证据评估过程中的透明度和效率.
- "可用性"被确定并添加为关键标准,与世卫组织EML选择原则保持一致.
结论:
- 在EML应用中,EtD框架和视觉摘要是增强证据沟通和决策的宝贵工具.
- 采用EtD框架可以使EML流程与健康实践指南保持一致,减少重复和改善协调.
- 通过强大,透明和基于证据的方法加强EML开发对于全球健康影响和药物获取至关重要.
相关概念视频
Preclinical Development: Overview
4.4K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.4K
Clinical Trials: Overview
3.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.0K
Drug Discovery: Overview
7.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.9K
Clinical Trials
6.7K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.7K
Structure-Activity Relationships and Drug Design
726
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
726
Drug Regulation
1.4K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.4K


