在急性缺血性中风患者的腹部脂肪和临床结果之间存在关联
Kayo Wakisaka1,2, Ryu Matsuo1,3,4, Fumi Irie1,3,4
1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
PloS one
|January 11, 2024
概括
腹部脂肪,通过腰围来衡量,独立地改善中风的结果. 更高的腰围与中风后更好的功能恢复有关,无论身体质量指数如何.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 腹部肥胖对中风后预后的独立影响尚不清楚.
- 腰围 (WC) 是腹部脂肪积累的一个关键指标.
研究的目的:
- 调查腰围 (WC) 与急性缺血性中风后的临床结果之间的独立关联.
主要方法:
- 日本一家多中心医院的中风注册中心注册了11,989名急性缺血性中风患者.
- 根据男性和女性的WC四分位数 (Q1-Q4) 将患者分为四组.
- 调整后勤回归分析以考虑混因素,包括身体质量指数 (BMI),以评估功能不良和全因死亡等结果.
主要成果:
- 较高的WC (Q2-Q4与Q1) 与退院时和3个月后功能表现不佳的风险降低有关,独立于BMI.
- 在调整了BMI后,WC与所有原因死亡风险降低之间的关联减弱了.
- 在非糖尿病患者中观察到高WC对功能结果的有益影响,并且不受胰岛素抵抗标志物的影响.
结论:
- 腹部脂肪,以WC表示,在缺血性中风后对功能结果有显著的,独立的影响.
- 这种影响与总体体重 (BMI) 和诸如胰岛素抵抗等代谢因素不同.
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