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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Abnormal Proliferation02:23

Abnormal Proliferation

4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

527
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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相关实验视频

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Enhancing Tumor Content through Tumor Macrodissection
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瘤微环境组成和功能背后的遗传机制在扩散大B细胞淋巴瘤中的功能.

Leandro Cerchietti1

  • 1Hematology and Oncology Division, Medicine Department, New York-Presbyterian Hospital, Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY.

Blood
|January 11, 2024
PubMed
概括

淋巴瘤细胞内的遗传因素显著影响扩散型大B细胞淋巴瘤 (DLBCL) 的瘤微环境 (TME). 了解这种关系是开发改善DLBCL患者免疫疗法的关键.

科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 遗传学 遗传学 是一个

背景情况:

  • 扩散性大B细胞淋巴瘤 (DLBCL) 中的瘤微环境 (TME) 是高度多样化和可塑性的.
  • 患者年龄,免疫状况和治疗等因素会影响TME,但淋巴瘤细胞内的遗传驱动因素至关重要.

结论:

  • 更深入地了解DLBCL遗传因素与TME生物学之间的相互作用至关重要.
  • 预计这些知识将有助于开发有针对性的治疗干预措施,特别是免疫疗法.

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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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相关实验视频

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