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Updated: Jul 28, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
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酶域的基向定位:来自in silico研究的见解和与实验的比较

Ji Young Lee1, Emma Gebauer2, Markus A Seeliger2

  • 1Laufer Center for Physical & Quantitative Biology, Department of Biochemistry and Cell Biology, School of Medicine, Stony Brook University, NY 11794, USA.

Current opinion in structural biology
|January 11, 2024
PubMed
概括

向全位 (allo-targeting) 提供了一种有希望的策略,以克服蛋白激酶域药物发现的局限性,特别是当与用于识别有效全位调节器的计算方法相结合时.

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相关概念视频

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...