关于FOXD2-AS1在人类疾病中的作用的综述
Soudeh Ghafouri-Fard1, Atefeh Harsij1, Bashdar Mahmud Hussen2
1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pathology, research and practice
|January 11, 2024
概括
长非编码RNA的FOXD2-AS1在大多数癌症中被上调,促进恶性特征和耐药性. 它影响了对癌症进展和干性至关重要的多个信号通路.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 邻FOXD2对面链RNA1 (FOXD2-AS1) 是一个长的非编码RNA,位于染色体1p33.3.
- 这种转录在广泛的人类恶性瘤中显著上调.
- 它的高表达与瘤恶性特征的增加有关.
研究的目的:
- 总结FOXD2-AS1在各种人类疾病中的多方面的影响.
- 突出其在癌症进展和治疗耐药性方面的作用.
主要方法:
- 文献综述和对FOXD2-AS1.1.现有研究的综合.
- 对与FOXD2-AS1.1.相关的基因表达数据和通路分析的分析.
- 对研究FOXD2-AS1在癌症干细胞特性和上皮细胞-介质细胞转变中的作用的研究进行了综述.
主要成果:
- FOXD2-AS1失调会影响关键的与癌症相关的信号通路,包括PI3K/AKT,AKT/mTOR,Hippo/YAP,Notch,NRf2,Wnt/β-catenin,NF-ƙB和ERK/MAPK.
- 它增强了癌症干细胞的特性,促进了瘤的开始和复发.
- 福克斯D2-AS1赋予了对多种化疗剂的耐药性,如阿德里亚米辛,西斯普拉丁,5-甲,temozolomide和gemcitabine.
结论:
- FOXD2-AS1是一种关键的瘤性 lncRNA,涉及各种癌症的进展和治疗挑战.
- 它对基本的癌症途径和耐药性机制的参与使其成为潜在的治疗目标.
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