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对于激素受体阳性/人表皮生长因子受体2-阴性转移性乳腺癌的当前和新兴治疗方法

Komal Jhaveri¹, Frederik Marmé²

¹Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Cancer treatment reviews

|January 11, 2024

概括

新的抗体药物合物为激素受体阳性,HER2阴性转移性乳腺癌 (mBC) 提供了改进的治疗方法,解决了内分泌阻断性疾病和未满足需求.

科学领域:

在瘤学瘤学.
医学治疗学医学治疗学
乳腺癌研究研究乳腺癌研究

背景情况:

在治疗HR+/HER2-mBC方面取得了重大进展,但临床问题仍然存在.
循环素依赖性激酶4/6抑制剂加上内分泌疗法 (ET) 是标准的第一线治疗,改善了生存率.
内分泌阻断性疾病仍然是一个具有有限有效选择的挑战.

研究的目的:

审查HR+/HER2-mBC当前的治疗选择.
讨论影响实践的最新数据和新型治疗剂.
提供对未来方向的洞察力,并解决未满足的需求.

主要方法:

审查当前的文献和临床试验数据.
对新型治疗药物的分析,包括口服SERD和抗体-药物合物.
讨论治疗顺序和抵抗机制.

主要成果:

新的口服选择性雌激素受体下调调剂 (SERD) 如elacestrant正在出现ESR1-突变的mBC.
抗体药物合物,特拉斯图祖马布德鲁克斯坦和萨基图祖马布戈维特肯,对HR+/HER2-low和HR+/HER2-mBC,包括后一线设置,显示出有希望.
这些药物提高了瘤的选择性和疗效,特别是在内分泌阻断性疾病中.

结论:

抗体-药物合物的进步为HR+/HER2-mBC提供了新的治疗选择,特别是在内分泌耐药环境中.
需要对新型药物的最佳测序和理解耐药机制进行进一步的研究.
解决后期治疗的未满足需求仍然是改善患者治疗结果的关键重点.

关键词:

抗体与药物的结合物.内分泌耐药性内分泌耐药性具有激素受体阳性的人.转移性乳腺癌是发生转移的萨西图祖马布 (Sacituzumab) govitecan也可以使用.特拉斯图祖马布可以脱.

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