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针对癌症免疫治疗的HDAC向表观遗传调节器

Binbin Cheng1, Wei Pan2, Yao Xiao3

  • 1School of Medicine, Hubei Polytechnic University, Huangshi, 435003, PR China; Key Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui People's Hospital, Lishui, Zhejiang, 323000, PR China; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035, PR China.

European journal of medicinal chemistry
|January 11, 2024
PubMed
概括

基斯脱乙酶 (HDAC) 抑制剂在癌症免疫治疗中表现有前途,但面临有效性和毒性问题. 较新的组合疗法和像PROTACs这样的HDAC调节剂提供了更好的结果,是未来癌症治疗策略的关键.

关键词:
癌症免疫疗法癌症免疫疗法双重作用剂是双重作用剂.在HDAC的基础上,HDAC是这就是PROTAC.

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