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精神分裂症和自闭症的多感官整合缺陷在行为中得到证实,但不是与事件相关的潜力

Maida Toumaian¹, Panagiotis Covanis², Asimakis Mantas²

¹Laboratory of Cognitive Neuroscience and Sensorimotor Control, University Mental Health, Neurosciences and Precision Medicine Research Institute "COSTAS STEFANIS", Athens, Greece; 1st Department of Psychiatry, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece.

Psychiatry research

|January 11, 2024

概括

自闭症谱系障碍 (ASD) 和精神分裂症 (SCZ) 患者在多感官整合 (MSI) 中表现出显著的缺陷,影响反应时间. 这些在ASD和SCZ的行为缺陷并没有反映在早期的神经反应中,这表明后期处理阶段的参与.

科学领域:

神经科学是一个神经科学.
认知心理学认知心理学
精神病学是一个精神病学.

背景情况:

多感官集成 (MSI) 结合了来自不同感官的信息.
MSI在感知和认知中发挥着至关重要的作用.
在自闭症谱系障碍 (ASD) 和精神分裂症 (SCZ) 中,MSI 的缺陷已被建议.

研究的目的:

研究和比较自闭症谱系障碍 (ASD) 和精神分裂症 (SCZ) 患者的多感官整合 (MSI) 能力.
检查这些患者群体中MSI的行为 (反应时间) 和神经 (EEG) 相对应物.
为了确定健康对照 (HC),ASD和SCZ之间的MSI处理阶段的潜在差异.

主要方法:

对32名HC,35名SCZ患者和23名ASD患者进行了视听 (AV) 同步目标检测任务.
在单模和AV条件下记录了行为数据 (反应时间) 和电生理数据 (EEG).
采用了一种新的引导方法来量化个体MSI收益.

主要成果:

在AV条件下,多感官集成 (MSI) 导致健康对照组 (HC) 的反应时间 (RTs) 更快,更一致.
在78%的HC中观察到MSI增加,但在ASD (26%) 和SCZ (48%) 患者中显著减少.
神经测量显示,在HC中AVMSI期间,神经反应和P3反应得到增强,但这些神经效应与行为MSI收益无关,也无法解释患者的缺陷.

结论:

无论是ASD还是SCZ组,在行为多感官集成 (MSI) 中都表现出强大的缺陷.
这些行为缺陷并没有反映在早期的感知或认知电皮质反应中.
这些发现表明,ASD和SCZ的MSI损伤可能源于后期的处理阶段,例如响应选择.

关键词:

在 Bootstrap 中使用 Bootstrap.认知性P3反应反应多感应处理是多感应处理.神经发育障碍神经发育障碍种族模式不平等的不平等感官相关的潜力感官相关的潜力

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