在糖尿病前期的成年人中,虚弱和微血管疾病的风险
Pingting Zhong1, Riqian Liu2, Zhuoting Zhu3
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, 510000, Guangzhou, China; Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, 570311, Hainan Province, China.
脆弱性和脆弱性前期显著增加了患有糖尿病前期患者微血管疾病的风险. 即使是脆弱点的微小增长对于管理糖尿病前期健康结果也很重要.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
背景情况:
- 前糖尿病是一个日益严重的公共卫生问题,与微血管疾病的风险增加有关.
- 虚弱是一种生理储备下降和脆弱性增加的情况.
- 在糖尿病前期,脆弱性和微血管并发症之间的联系仍未得到充分研究.
研究的目的:
- 调查脆弱现象型与患有糖尿病前期的人群中微血管疾病 (MVD) 的发生率之间的联系.
- 为了确定特定的脆弱成分,介导MVD的风险.
- 检查虚弱对视网膜微血管变化的影响.
主要方法:
- 包括英国生物银行 (66,068名参与者) 和中国眼科成像项目 (226名参与者) 在内的前性队列研究.
- 使用弗里德表型评估的脆弱性 (减肥,疲劳,握力低,体力活动低,步行速度慢).
- 事件MVD (视网膜病变,病变,神经病变) 和视网膜毛细血管密度下降是主要结果;使用了Cox和混合线性模型.
主要成果:
- 虚弱前期和虚弱明显与较高的MVD风险相关 (HR分别为1.21和1.60).
- 虚弱增加了视网膜病变,病变和神经病变的风险 (调整后的HR分别为1.42,1.49和2.37).
- 疲劳和慢步是关键调解因素;较低的手握强度与视网膜毛细血管密度下降的更快相关.
结论:
- 在糖尿病前患者中,前脆弱性和脆弱性表型都是MVD的显著风险因素.
- 每一个脆弱点都会增加MVD风险,这凸显了早期干预的重要性.
- 减少手握强度是加速视网膜微血管损伤的特定指标.
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