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Updated: Jul 5, 2025

Characterizing Mutational Load and Clonal Composition of Human Blood
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对临床和多基因生殖系对体质突变负担的影响的综合分析

Kodi Taraszka1, Stefan Groha2, David King3

  • 1Department of Computer Science, University of California, Los Angeles, CA 90095, USA; Department of Medical Oncology, Dana-Farber Cancer Institute & Harvard Medical School, Boston, MA 02215, USA.

American journal of human genetics
|January 11, 2024
PubMed
概括

主体遗传和非遗传因素显著影响瘤突变负担 (TMB) 和副本数负担 (CNB). 这些因素影响癌症患者的结果,特别是免疫疗法患者的存活率,突显了生殖系遗传在体质进化中的作用.

关键词:
癌症 癌症 癌症 癌症 癌症副本编号负担的负担精细的祖先的祖先在一个很小的规模.总体存活率 总体存活率多基因风险得分的多基因风险得分.身体负担是一种体质负担.瘤突变负担的突变负担

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