从Byrsonima coccolobifolia叶子提取物中获得的针对COVID-19的潜在抗病毒
Clenilson Martins Rodrigues1, Charlyana Carvalho Bento2, Carolina Borsoi Moraes3
1Laboratory of Chemistry and Biomass and Biofuels, Embrapa Agronergy, Brazilian Agricultural Research Corporation, Brasília, DF, Brazil.
Fitoterapia
|January 11, 2024
概括
比尔索尼马 (Byrsonima coccolobifolia) 树叶提取物显示出对Cryptococcus neoformans的抗真菌活性,以及对导致COVID-19的病毒SARS-CoV-2的抗病毒作用. 这种天然化合物有望治疗真菌感染和病毒性疾病.
科学领域:
- 药理学和植物化学
- 自然产品化学 自然产品化学
- 传染性疾病 传染性疾病
背景情况:
- 像COVID-19这样的新兴传染病需要新的治疗策略.
- 人类病原体的抗真菌耐药性构成了全球重大健康挑战.
- 药用植物是具有治疗潜力的生物活性化合物的丰富来源.
研究的目的:
- 为了研究Byrsonima coccolobifolia原始甲醇叶提取物的抗真菌和抗病毒特性.
- 为了确定对观察到的生物活性负责的化学成分.
- 评估提取物对人类病原菌和SARS-CoV-2的疗效.
主要方法:
- 使用高性能液态染色学 (HPLC) 和质谱学 (MS) 的植物化学分析.
- 调料稀释试验以确定抗真菌活性 (IC50).
- 在体外测试和分子对接研究以评估针对SARS-CoV-2 (EC50) 的抗病毒活性.
主要成果:
- 提取物中含有烯酸衍生物,甲基因衍生物,氨酸,氨酸和类糖化物.
- 对Cryptococcus neoformans (IC50 = 4μg/mL) 观察到显著的抗真菌活性.
- 提取物在体外表现出针对SARS-CoV-2的抗病毒活性 (EC50 = 7μg/mL),具有高选择性 (>90%).
结论:
- 拜尔索尼马 (Byrsonima coccolobifolia) 树叶提取物具有显著的抗真菌和抗病毒特性.
- 鉴定出的植物化学物质可能有助于观察到的治疗效果.
- 这种提取物代表了开发用于真菌感染和COVID-19的新治疗方法的潜在自然来源.
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