神经营养素-3进入岛屿皮层加强了受条件的味觉厌恶记忆
María G Briones-Vidal1, Salma E Reyes-García1, Martha L Escobar1
1División de Investigación y Estudios de Posgrado, Facultad de Psicología, Universidad Nacional Autónoma de México 04510, Mexico.
Behavioural brain research
|January 11, 2024
概括
神经营养素3 (NT-3) 在岛屿皮层中增强厌恶性记忆的巩固. 这个过程依赖于Trk受体,将弱小的记忆转化为强大的记忆.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 行为科学 行为科学
背景情况:
- 记忆的巩固对于长期记忆的形成至关重要.
- 神经营养素调节突触可塑性,这是记忆中的关键机制.
- 岛内皮层 (IC) 对于有条件的味道厌恶 (CTA) 记忆至关重要.
研究的目的:
- 研究神经质蛋白3 (NT-3) 在IC内记忆巩固中的作用.
- 为了确定NT-3是否影响厌恶记忆的形成.
主要方法:
- 使用了成年雄性Wistar大鼠.
- 与Trk抑制剂K252a一起的NT-3或NT-3被用于IC后CTA获得.
- 在强 (0.2 M LiCl) 或弱 (0.1 M LiCl) 调节方案下诱导CTA.
主要成果:
- NT-3的使用加强了CTA的记忆痕迹.
- NT-3将弱CTA条件转化为强条件.
- 这种效应取决于Trk受体活性.
结论:
- NT-3在厌恶性记忆巩固中起着重要作用.
- 这种整合发生在一个新皮层区域内,即IC.
- NT-3通过Trk受体作用,调节记忆强度.
更多相关视频
09:22A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
Published on: June 22, 2015
14.7K
08:07Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
Published on: August 24, 2016
9.1K
相关概念视频
Conditioned Taste Aversion
143
Conditioned taste aversion, also known as sauce béarnaise syndrome, is a phenomenon in which an individual develops an aversion to a certain food taste following a negative experience, typically illness. This form of aversion is a type of classical conditioning in which the taste of the food (conditioned stimulus, CS) is associated with the experience of illness (unconditioned stimulus, UCS).
A notable characteristic of conditioned taste aversion is that it often requires only a single...
A notable characteristic of conditioned taste aversion is that it often requires only a single...
143
The Physiology of Taste
3.9K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
3.9K
