在眼科手术前最大限度地减少眼睛表面细菌负荷的局部消毒剂:随机对照试验
Vito Romano1, Mariantonia Ferrara2, Francesca Gatti3
1From the Eye Unit, ASST Spedali Civili di Brescia (V.R., F.S.), Brescia, Italy; Eye Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia (V.R., Fr.G., F.S.), Brescia, Italy.
American journal of ophthalmology
|January 11, 2024
概括
赫西丁 (CLX) 0.02%显著降低了手术前的眼睛表面细菌负荷,与波维 (PVI) 0.6%相比. 此外,CLX的耐受性更好,眼内外科手术的患者报告的眼部症状较少.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 手术准备 手术准备
背景情况:
- 眼睛表面的细菌污染构成手术后感染的风险.
- 在眼科手术前使用消毒剂来减少细菌负载.
研究的目的:
- 为了比较波维- (PVI) 0.6%和 (CLX) 0.02%在减少眼睛表面细菌负荷方面的疗效.
- 在接受眼内外科手术的患者中评估这些杀菌剂配方的耐受性.
主要方法:
- 一项随机对照试验,涉及70名接受眼内外科手术的成年患者.
- 在手术前3天,患者在指数眼中接受PVI0.6%或CLX0.02%的治疗.
- 用实时PCR分析结合膜拭子,以量化治疗前后的微生物DNA.
主要成果:
- 0.02%的CLX显著降低了眼睛表面的细菌负荷 (平均CT差异为0.99),而PVI 0.6%没有 (平均CT差异为0.26).
- 细菌的分类学组成和多样性在两组中都保持稳定.
- 与PVI (97%) 相比,显著较少的患者报告了CLX (26%) 的眼部症状,平均不适度较低.
结论:
- 赫西丁0.02%比povidone-iodine 0.6%更有效地减少眼睛表面细菌在眼内手术前.
- 与PVI 0.6%相比,CLX 0.02%提供了更好的耐受性和患者舒适性.
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