在血液溶解样本中精确校正血度的模型
Mulatijiang Maimaiti1, Boxin Yang1, Tong Xu1
1Department of Laboratory Medicine, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, PR China.
Clinica chimica acta; international journal of clinical chemistry
|January 11, 2024
概括
血液样本中的血液溶解显著影响水平的准确性. 数学模型,特别是曲线拟合,可以准确地纠正这些值,改善临床解释和患者护理.
科学领域:
- 临床化学 临床化学
- 生物医学工程 生物医学工程
- 医学诊断 医学诊断 医学诊断
背景情况:
- 样本血液溶解可能会严重影响血液度.
- 与结果的干扰可能导致误解和延迟治疗.
- 对重症患者来说,重新抽取样本往往是不可行的.
研究的目的:
- 开发一种数学模型,以快速纠正血液样本中的度.
- 为了解决测试中样品血液溶解所带来的临床挑战.
- 在具有挑战性的采集场景中提高测试结果的可靠性.
主要方法:
- 收集了来自107名患者的残留血液样本.
- 通过超声波压碎来诱导不同程度的血液溶解.
- 使用SPSS和MATLAB开发了线性回归和曲线拟合模型.
- 经过验证的模型与85名患者样本的独立集合.
主要成果:
- 线性回归模型显示高相关性 (R2 = 0.9749) 准确率为96.5%.
- 曲线适配模型实现了100%的准确性,与测量值没有统计差异 (p=0.552).
- 所有使用曲线拟合模型验证的样本都在6% TEa内.
结论:
- 线性回归和曲线拟合模型都有效地纠正血液化样本中的.
- 曲线适配模型表现出卓越的准确性和可靠性.
- 这些模型为精确的测量提供了宝贵的工具,尽管样品血液溶解.
相关概念视频
Determining the pH of Salt Solutions
43.6K
The pH of a salt solution is determined by its component anions and cations. Salts that contain pH-neutral anions and the hydronium ion-producing cations form a solution with a pH less than 7. For example, in ammonium nitrate (NH4NO3) solution, NO3− ions do not react with water whereas NH4+ ions produce the hydronium ions resulting in the acidic solution. In contrast, salts that contain pH-neutral cations and the hydroxide ion-producing anions form a solution with a pH greater than...
43.6K
Buffer Effectiveness
49.0K
Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
The buffer capacity is the amount of acid or base that can be added to a given volume...
49.0K
Weak Base Solutions
22.7K
Some compounds produce hydroxide ions when dissolved by chemically reacting with water molecules. In all cases, these compounds react only partially and so are classified as weak bases. These types of compounds are also abundant in nature and important commodities in various technologies. For example, global production of the weak base ammonia is typically well over 100 metric tons annually, being widely used as an agricultural fertilizer, a raw material for chemical synthesis of other...
22.7K


