早期的亲肠道营养与出生时体重非常低的婴儿的增长有所改善:一项回顾性研究
René Liang Shen1, Christian Ritz2, Yanqi Li1,3
1Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Archives of disease in childhood. Fetal and neonatal edition
|January 11, 2024
概括
非常低出生体重 (VLBW) 婴儿的早期亲肠道营养 (PN) 与更好的住院生长有关. 这项针对VLBW新生儿的研究发现,随着及时启动PN,体重z分数得到改善.
科学领域:
- 新生儿科学 新生儿科学
- 儿童营养学 儿童营养学
- 增长和发展 增长和发展
背景情况:
- 非常低出生体重 (VLBW) 的婴儿面临着实现适当生长的挑战.
- 亲肠道营养 (PN) 对于VLBW新生儿的营养支持至关重要.
- 在VLBW婴儿中启动PN的最佳时间仍然是一个研究领域.
研究的目的:
- 评价早期亲肠道营养 (PN) 与极低出生体重 (VLBW) 的早产婴儿的身体生长之间的关联.
主要方法:
- 对来自13家国际医院的NeoNutriNet队列 (2011-2014) 进行了因果推断分析.
- 包括新生儿在内的新生儿出生时体重≤1500g.
- 早期PN (24小时内) 与延迟PN (2-5天) 相比较.
主要成果:
- 早期PN启动与36周月经后年龄 (PMA) 和4周校正年龄 (CA4) 的体重z分数有显著的改善有关.
- 在36周PMA和CA4的早期PN时,观察到增长速度 (GV) 的改善.
- 在早期PN和死亡率,死性肠球炎 (NEC) 或抗生素使用之间没有发现显著的关联.
结论:
- 在生命的第一天内启动亲肠道营养与VLBW婴儿的医院生长增强有关.
- 早期的PN可能是一个有益的策略,以改善这个脆弱人群的增长结果.
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