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Updated: Jul 5, 2025

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
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Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

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单分子局部化显微镜揭示了STING在跨戈尔吉网络的聚类,通过棕化取决于胆固醇的积累

Haruka Kemmoku1, Kanoko Takahashi1, Kojiro Mukai1

  • 1Laboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.

Nature communications
|January 11, 2024
PubMed
概括

干扰素基因 (STING) 蛋白质聚集在戈尔吉激活器激活免疫信号. 这一过程需要STING棕化和胆固醇,增强TBK1与先天免疫的关联.

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相关概念视频

Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
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