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Updated: Jul 5, 2025

Expanding the Toolkit for In Vivo Imaging of Axonal Transport
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Expanding the Toolkit for In Vivo Imaging of Axonal Transport

Published on: December 23, 2021

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TSC1和TSC2蛋白在神经元轴突中的作用

Vasiliki Karalis1,2, Delaney Wood2,3, Nicole A Teaney1,2

  • 1Rosamund Stone Zander Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Molecular psychiatry
|January 11, 2024
PubMed
概括

结核性硬化综合体 (TSC) 蛋白质TSC1和TSC2调节神经元的发育. 本综述探讨了它们在轴突形成和完整性中的关键作用,将TSC/mTOR信号与神经发育障碍联系起来.

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Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

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Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
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