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上腺静脉采样:非上腺静脉样本的位置是否重要?
Florian Wernig1,2, Aleksandra Dunin-Borkowska3, Angelos Frisiras3
1Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK.
上腺静脉采样 (AVS) 的结果是可比的,无论是标准化到下下静脉 (IVC) 或右外阴静脉 (REIV). 这一发现支持这些参考部位在AVS中可互换的初级阿尔多斯特主义.
科学领域:
- 内分泌学 在内分泌学.
- 干预性放射学 干预性放射学
背景情况:
- 上腺静脉采样 (AVS) 对于初级阿尔多斯质症中横向阿尔多斯激素的产生至关重要.
- 对AVS的标准化依赖于将上腺静脉样本与外周或下下静脉 (IVC) 样本进行比较.
- 非上腺样本位置对AVS结果的影响尚不清楚.
研究的目的:
- 为了比较上腺静脉采样 (AVS) 结果,当标准化为低IVC与右外阴静脉 (REIV) 时.
- 为了确定参考静脉的选择是否会影响对阿尔多素生产侧向化的评估.
主要方法:
- 在2021年3月至2023年5月期间接受AVS的81名患者的回顾性分析.
- 所有由单个操作员执行的程序.
- 低IVC和REIV参考样本之间的皮质醇和阿尔多斯特水平使用同等性测试进行了比较.
主要成果:
- 在97.5%的病例中,成功的双边上腺静脉管.
- 在低IVC和REIV标准化之间的统计学上相当的皮质醇和阿尔多斯特水平.
- 无论使用何种参考静脉,选择性或侧面化发现都没有不一致.
结论:
- 低IVC和REIV样本可以互换,用于标准化AVS.
- 这种可互换性简化了AVS程序,而不会影响原发性阿尔多斯特主义的诊断准确性.
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