更年期荷尔蒙疗法和沙尔科病的风险:瑞典的一项基于人口的嵌套病例对照研究
Marina Dehara1, Susanna Kullberg2,3,4, Marie Bixo5
1Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital T2, 171 76, Stockholm, Sweden. marina.dehara@ki.se.
European journal of epidemiology
|January 11, 2024
概括
更年期激素治疗 (MHT) 的使用,特别是全身雌激素,与女性患上沙尔科毒症的风险增加有关. 这表明有潜在的荷尔蒙影响在更年期期间的 Sarcoidosis 的发展.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 自免疫性疾病流行病学
- 药理学风险评估 药理学风险评估
背景情况:
- 在更年期,一种荷尔蒙转变的时期, सारकॉइडोसिस发病率在更年期达到顶峰.
- 雌激素是一种关键的性激素,与自身免疫性疾病的发展有关.
- 更年期荷尔蒙治疗 (MHT) 与沙尔科毒症风险之间的关联尚不清楚.
研究的目的:
- 为了调查MHT使用与女性肉类突症风险之间的关联.
- 为了确定MHT类型和给药途径是否会影响类病的风险.
主要方法:
- 嵌套病例控制研究 (2007-2020年) 使用瑞典国家注册.
- 与对照组 (n=20,003) 相匹配的发生性 Sarcoidosis 的病例 (n=2593).
- 从瑞典处方药登记册分析的MHT处方;通过条件后勤回归计算的调整的几率比率 (aOR).
主要成果:
- 曾经使用MHT与麻症的风险增加25%有关 (aOR 1.25).
- 系统性雌激素的风险最高 (aOR 1.51),其次是局部雌激素 (aOR 1.25).
- 与从未使用者相比,全身雌激素-孕激素联合治疗显示出最低的风险 (aOR 1.12) .
结论:
- 过去使用MHT的病史与类发病的风险增加有关.
- 系统性雌激素的使用似乎在MHT类型中具有最高的风险.
- 研究结果表明,荷尔蒙因素,特别是雌激素,在沙尔科毒症的发病过程中起着作用.
更多相关视频
05:32Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
Published on: August 11, 2023
1.8K
06:51Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration
Published on: June 7, 2012
57.6K
相关概念视频
01:28Menopause
166
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
166
01:24Disorders of the Female Reproductive System
364
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
364
01:12Hazard Ratio
128
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
128