在有异常精子参数的男性中,精液微生物群发生了显著的变化
Vadim Osadchiy1, Andre Belarmino1, Reza Kianian1
1Division of Andrology, Department of Urology, David Geffen School of Medicine, University of California, 10945 Le Conte Avenue, Ueberroth #3361, Los Angeles, CA, 90095, USA.
Scientific reports
|January 11, 2024
概括
精液微生物组与异常的精子参数有关. 增加Lactobacillus iners的丰富度与精子运动不佳相关,而特定的Pseudomonas物种与精子度的改变有关,可能会影响男性生育能力.
科学领域:
- 生殖医学 生殖医学
- 微生物组研究 微生物组研究
- 安德罗学与人类学
背景情况:
- 人类微生物组在健康和疾病中的作用越来越被认可.
- 在30%的病例中,异常精液分析 (SA) 参数的病因仍未确定.
- 研究精液微生物组可能会阐明精子参数受损的原因.
研究的目的:
- 探索精液微生物组与精子参数变化之间的关系.
- 为了确定与异常的精子运动和度相关的特定微生物特征.
主要方法:
- 招募男性进行生育能力评估或输精管切除咨询.
- 进行精液分析 (SA) 和下一代测序用于微生物组概况.
- 微生物群组合的利用分析与偏差校正 (ANCOM-BC) 和正规的相关性分析.
主要成果:
- 异常的精子运动与更高的乳酸菌内置者的丰度有关 (9.4%对2.6%,p=0.046).
- 异常的精子度与Pseudomonas stutzeri (2.1%对1.0%,p=0.024) 和Pseudomonas fluorescens (0.9%对0.7%,p=0.010) 的增加相关.
- 在具有异常精子度 (0.5%对0.8%,p=0.020) 的男性中观察到Pseudomonas putida的丰度较低.
结论:
- 特定的微生物,特别是乳杆菌和伪虫物种,可能会极大地影响精液分析参数.
- 研究结果表明,改善男性生育能力的潜在微生物目标.
- 对精液微生物组的进一步研究可能会导致新的治疗策略.
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