怀孕期间和产后指甲皮质醇水平的时间变化
Shuhei Izawa1, Mikiko Kawasaki2,3, Nagisa Sugaya4
1Occupational Stress and Health Management Research Group, National Institute of Occupational Safety and Health, Kawasaki, Japan. izawa@h.jniosh.johas.go.jp.
Scientific reports
|January 11, 2024
概括
指甲皮质醇水平跟踪身体的长期激素变化,分娩后增加,产后达到顶峰. 这项研究支持指甲皮质醇作为激素产生的追溯指数.
科学领域:
- 内分泌学 在内分泌学.
- 生物标志物研究 生物标志物研究
- 生殖健康 生殖健康
背景情况:
- 指甲中的皮质醇提供了累积激素生产的回顾性测量.
- 以前的研究集中在横截面关联上,缺乏纵向数据.
- 怀孕为研究长期的荷尔蒙变化提供了一个独特的模型.
研究的目的:
- 为了研究怀孕期间和产后期指甲皮质醇水平的纵向变化.
- 评估指甲皮质醇与皮质醇预期的生理变化之间的相关性.
- 为了比较第一次母亲 (primiparas) 和多个孩子的母亲 (multiparas) 之间的指甲皮质醇水平.
主要方法:
- 在怀孕期间和产后12个月内从30名健康妇女收集指甲样本.
- 在指甲切片中测量皮质醇水平.
- 对纵向变化的分析和参与者群体之间的比较.
主要成果:
- 指甲皮质醇水平从产前一个月到产后四个月显著增加.
- 在指甲切片中的皮质醇水平在分娩后大约两个月达到峰值.
- 较高的指甲皮质醇水平在primiparas被观察到,而不是multiparas.
结论:
- 指甲皮质醇水平的时间模式有效地反映了身体皮质醇生产的纵向变化.
- 观测到的primiparas和multiparas之间指甲皮质醇的差异表明生物可信性.
- 指甲皮质醇作为一个可行的回顾性生物标志物,用于评估长期的激素产量.
相关概念视频
01:22Hormonal Regulation of the Menstrual Cycle
396
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
396
01:27Ovarian Cycle
1.2K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.2K
01:27Introduction to Stress and Lifestyle
115
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
115