后COVID dysautonomies:我们知道的和 (主要是) 我们不知道的
1Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. goldsteind@ninds.nih.gov.
Nature reviews. Neurology
|January 11, 2024
概括
长期COVID,或SARS-CoV-2感染 (PASC) 后急性后续,呈现出各种症状,可能与自主神经系统 (ANS) 功能障碍有关. 本综述探讨了PASC中的ANS异常,为其在该条件中的作用提供了一个理论框架.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 生理学 生理学 生理学
背景情况:
- SARS-CoV-2 感染 (PASC) 或长期COVID的后急性后果是一个全球性的健康问题,它具有影响多个器官的多种症状.
- 帕斯克的异质性表明自主神经系统 (ANS) 的潜在参与,这对于维持平衡至关重要.
- 关于PASC中ANS失调的先前研究是有限的,通常是观察性的,只关注心血管措施,忽视其他ANS组件.
研究的目的:
- 审查有关后COVID综合征患者自主神经系统异常的当前文献.
- 呈现ANS在PASC的共同特征中的潜在作用的理论视角.
- 突出需要更全面地了解ANS参与的必要性,包括上腺,激素和肠道功能.
主要方法:
- 对研究后COVID综合征中自主神经系统功能的文献综述.
- 对PASC症状和间接心血管措施的观察和描述数据的分析.
- 现有知识的理论综合,为ANS参与PASC提出一个框架.
主要成果:
- 自主神经系统 (ANS) 失调越来越被认为是SARS-CoV-2感染 (PASC) 后急性后果的一个重要因素.
- 现有的研究往往忽略了关键的ANS组件,如上腺,激素和肠道神经系统.
- 需要对自主功能障碍采取综合症的方法,才能充分理解PASC复杂的表现.
结论:
- 自主神经系统 (ANS) 可能在长期COVID (PASC) 的各种表现中发挥着关键作用.
- 进一步的研究应该采用全面的方法,检查ANS的所有方面,以阐明其参与PASC.
- 了解ANS异常对于开发PASC有效的治疗策略至关重要.
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