住院COVID-19患者的临床特征:不同年龄组之间的比较
Ginevra Fabiani1, Carolina Cogozzo1, Anna De Paris1
1High-Dependency Unit, Department of Clinical and Experimental Medicine, Careggi University Hospital, Lg. Brambilla 3, 50134, Florence, Italy.
BMC geriatrics
|January 11, 2024
概括
已知的COVID-19预后因素,如呼吸衰竭和病,在不同年龄组中具有不同的重要性. 脏疾病始终预测死亡率,而呼吸系统问题在年轻和年长的COVID-19患者中显著.
科学领域:
- 内部医学 内部医学
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- COVID-19的预后受到各种临床因素的影响.
- 这些因素的预测能力在不同患者年龄组之间可能有所不同.
- 了解特定年龄的预后因素对于有效的COVID-19管理至关重要.
研究的目的:
- 评估已建立的COVID-19预后标志物是否在不同年龄层保持其预测能力.
- 确定COVID-19患者住院死亡率的年龄相关预后因素.
主要方法:
- 对2225名在大学医院住院的COVID-19患者的回顾性分析 (2020年2月 - 2021年5月).
- 对二分化参数的分析:SpO2/FiO2比率,肌素,乳酸脱酶 (LDH) 和C反应蛋白 (CRP).
- 患者被分为四个年龄组 (18-57岁,57-71岁,72-81岁,>82岁),以评估住院死亡率.
主要成果:
- 单变量分析显示,所有测试变量的死亡率与所有年龄组的死亡率存在显著关联.
- 多变量分析揭示了特定于年龄的独立预测因素:最年轻和最年长的SpO2 / FiO2,最年轻的肌素和老年人的CRP.
- 功能障碍 (肌素≥1.1 mg/dL) 是所有年龄组死亡率的一致预测因素.
结论:
- 呼吸衰竭 (低SpO2/FiO2) 是一个显著的死亡预测因素,主要在最年轻和最老的COVID-19患者中.
- 功能障碍在医院死亡率方面表现出一致且独立的预后作用,无论患者的年龄如何.
- 年龄分层分析完善了对COVID-19中预后标记器实用性的理解.
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