伴随性疾病增加肺结核的风险:使用多源大数据的嵌套病例对照研究
Bao-Yu Wang1,2, Ke Song1,2, Hai-Tao Wang2
1Institute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
某些疾病显著增加肺结核 (PTB) 的风险. 这项研究确定了与较高PTB发病率相关的特定并发症和集群,突出了加强监测的必要性.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染病研究 传染病研究
背景情况:
- 肺结核 (PTB) 的风险受先前存在的医疗条件的影响.
- 没有先前的系统研究全面检查了与PTB相关的并发症或它们的集群模式.
研究的目的:
- 调查伴随性疾病与患肺结核的风险之间的联系.
- 确定可能增加PTB风险的并发症集群.
主要方法:
- 一项嵌套的病例控制研究利用了2013-2017年多个来源的大数据.
- 倾向性得分匹配 (PSM) 用于为事件PTB病例选择对照.
- 伴随性疾病使用ICD-10代码进行分类;纵向和回归分析确定了关联和集群.
主要成果:
- 该研究包括4265例PTB病例和17060例对照.
- 多重病变与增加PTB风险显著相关 (aOR 2.85-5.16).
- 14种特定的并发症与PTB有显著的关联 (aOR 1.28-7.27),根据性别和年龄的差异. 在呼吸,循环和内分泌/代谢系统中出现了三个群体.
结论:
- 多种并发性疾病,特别是影响呼吸,循环和内分泌/代谢系统的疾病,显著增加PTB风险.
- 提高对伴随性疾病的认识和监测对于早期PTB预防和控制至关重要.
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