加快的免疫衰老与COVID-19疾病的严重程度有关
Janet M Lord1,2,3, Tonny Veenith3, Jack Sullivan1
1MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Office 6, University of Birmingham Research Labs, Institute of Inflammation and Ageing, Queen Elizabeth Hospital, Birmingham, UK.
严重的COVID-19幸存者表现出增强的免疫衰老,其特征是改变的T细胞和NK细胞群. 这种通过IMM-AGE得分测量的免疫衰老在严重病例中显著高,这表明与SARS-CoV-2感染的联系.
科学领域:
- 免疫学 免疫学 免疫学
- 老年学是指老年学的学科.
- 传染性疾病 传染性疾病
背景情况:
- COVID-19的严重程度不成比例地影响着老年人,突出显示了免疫发育 (与年龄相关的免疫系统衰退) 的作用.
- 了解幸存者的免疫衰老与急性疾病严重程度之间的联系对于管理感染后结果至关重要.
研究的目的:
- 为了研究COVID-19幸存者的免疫表型.
- 描述康复期免疫衰退与COVID-19疾病严重程度之间的关联.
- 为了比较幸存者的免疫细胞简介与非感染的对照.
主要方法:
- 从103名COVID-19幸存者 (康复后3-5个月) 和59名健康对照者身上获得的外周血液单核细胞的详细免疫表型.
- 根据疾病,将幸存者分为严重,中度或轻度疾病组.
- 评估免疫细胞表型,以计算免疫衰老的复合IMM-AGE得分.
主要成果:
- 与对照组相比,严重的COVID-19幸存者表现出显著增加的免疫衰老标志物,包括减少的天真T细胞和增加的衰老T细胞 (CD28-CD57+) 和耗尽的CD8T细胞.
- 在严重的幸存者中观察到更高的记忆B细胞频率,衰老的NK细胞,以及Th17极化增加两倍.
- 在严重的COVID-19幸存者中,IMM-AGE得分显著更高;疾病严重程度和南亚种族是关键影响因素.
结论:
- 严重COVID-19的幸存者表现出增强免疫衰老的状态,可能是由SARS-CoV-2感染引起的.
- 这些发现支持进一步调查抗免疫衰老干预措施,以改善严重COVID-19患者的临床结果.
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