认知障碍患者的认知训练和大脑刺激:一种随机对照试验
Daria Antonenko1, Anna Elisabeth Fromm2, Friederike Thams2
1Department of Neurology, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany. daria.antonenko@med.uni-greifswald.de.
Alzheimer's research & therapy
|January 11, 2024
概括
结合跨直流刺激 (tDCS) 的认知训练并没有改善认知障碍患者的训练任务表现. 然而,在工作记忆中观察到好处,这表明tDCS在认知康复中的潜力.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 神经调节是一种神经调节.
背景情况:
- 认知障碍会影响日常功能.
- 非侵入性大脑刺激和认知训练显示了认知增强的潜力.
- 结合这些干预措施可能会带来协同效益.
研究的目的:
- 为了研究结合认知训练与经直流刺激 (tDCS) 在认知障碍患者的疗效.
- 评估训练任务的改进,并将效应转移到未经训练的认知功能.
- 探索静止状态功能连接的变化.
主要方法:
- 随机,模拟控制,双盲研究,对46名认知障碍患者 (60-80岁) 进行了随机,模拟控制,双盲研究.
- 干预:在3周的时间里进行9次认知训练,同时进行道tDCS (1mA) 或假刺激.
- 结果:在基线,干预后和随访时评估的训练任务性能,工作记忆 (N-back),决策,口头记忆和休息状态功能连接 (FC).
主要成果:
- 在tDCS和虚假组之间,训练任务执行没有显著差异.
- 在每协议tDCS组中观察到工作记忆 (N-back任务) 的显著改善.
- 与假药相比,tDCS组的前端双双体网络功能连接性增加.
- 发现个人记忆改善与tDCS电场大小之间的相关性.
结论:
- 结合认知训练和tDCS并没有提高认知障碍患者训练任务的表现.
- 探索性证据表明转移对工作记忆的影响,特别是在完成完整干预的人中.
- 这些发现表明tDCS诱导的神经网络调制和剂量依赖效应的潜力.
- 个性化方案可能是必要的,以优化治疗收益.
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