中性粒细胞与淋巴细胞的比率与有症状的囊性未破裂的内动脉瘤有关
De-Xiang Zheng1,2, Yi-Yang Lv3, Xiao-Jing Zhang4
1Department of Clinical Laboratory, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
European journal of medical research
|January 11, 2024
概括
中性粒细胞与淋巴细胞的比率 (NLR) 是症状未破裂的内动脉瘤 (UIA) 的关键指标. 这项研究发现,NLR独立地预测了症状性UIA,为动脉瘤进展和炎症提供了洞察力.
科学领域:
- 神经学 神经学
- 血管神经学 血管神经学
- 炎症研究 炎症研究
背景情况:
- 症状未破裂的内动脉瘤 (UIA) 可能会改变循环炎症,但这种联系尚未得到充分证实.
- 血液炎症标志物可能会预测UIA症状.
研究的目的:
- 研究血液炎症指标在预测症状性UIA中的作用.
- 评估NLR,LMR和症状性UIA状态之间的关联.
主要方法:
- 对150名成年患者的回顾性分析,这些患者患有囊状内动脉瘤.
- 收集临床和实验室数据,包括WBC,NEUT,LYM,MONO计数.
- 中性细胞与淋巴细胞比率 (NLR) 和淋巴细胞与单细胞比率 (LMR) 的计算,用于对症状和无症状UIA组进行比较.
主要成果:
- NLR和LMR与症状性UIA显著相关,特别是在较小的动脉瘤 (<7毫米) 中.
- 多变量逻辑回归证实了NLR作为症状性UIA的独立预测因素.
- 在ROC曲线分析中,确定了2.38的最佳NLR切线,用于区分症状和无症状UIA.
结论:
- 在NLR和症状性UIA之间存在显著的相关性.
- NLR是症状未破裂的内动脉瘤的独立预测器.
相关概念视频
Aneurysm I: Introduction
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Aneurysm III: Interprofessional Care
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
Aneurysm IV: Nursing Management
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...


